Pilot Projects

Every year JHU CCNE solicites proposals for pilot projects in cancer nanomedicine. Proposed projects should be innovative and must involve collaboration between two or more faculty with complementary expertise. Support of up to $50,000 per year direct costs may be requested for graduate student support, postdoctoral fellows or technicians, equipment, and/or for consumables. Recipients of pilot grants will be expected to submit a grant application to a federal funding agency or foundation through JHU CCNE.

Current Call

The Johns Hopkins Center of Cancer Nanotechnology Excellence (CCNE) at the Institute for NanoBioTechnology is soliciting proposals for pilot projects in cancer nanomedicine. Proposed projects should be innovative and must involve collaboration between two or more faculty with complementary expertise. Proposals in all areas of diagnostics and/or therapeutics will be considered. Applicants should include a statement of the nanotechnology innovation and the prospective clinical applications.

Please visit the CCNE website: http://ccne.inbt.jhu.edu/

• Applicants must have a current tenure or tenure-track appointment at
Johns Hopkins University.

• Proposals will be evaluated by the CCNE Executive Committee along
with an NCI representative.

• Support of up to $50,000 per year direct costs may be requested for
graduate student support, postdoctoral fellows or technicians,
equipment, and/or for consumables. Applicants may have the option to
re-apply for a second year of support. Recipients of pilot grants will
be expected to submit a grant application to a federal funding agency
or foundation through the CCNE.

• Applications should contain the following sections: (1)
Nanotechnology Innovation(s) (1- 2 sentences), (2) Prospective
Clinical Applications (1 – 2 sentences), (3) Specific Aims, (4)
Background (including preliminary studies), (5) Experimental Design
(refer to previous publications where possible), (6) Personnel (a
statement highlighting the complementary expertise of the
investigators), (7) References, and (8) Budget. The proposal should
begin with the project title and the names and e-mail addresses of the
investigators. The total length of items 1-6 should not exceed three
pages, using Arial 11 point font and 1/2 inch margins. In addition,
applicants should provide NIH Biosketches for the primary faculty
participants.

• Applications should be submitted as a single pdf file to: Sue Porterfield (sporterfield@jhu.edu)

Application Deadline: Friday, March 14, 2014.
Anticipated Project Start Date: Thursday, May 1, 2014.

Funded Pilot Projects 2012

  • ICG-nanocapsules for Aggressive Cancer Detection by Targeting Cell Surface Glycan Biomarker –  Xingde Li
  • In Situ Shape Transformation of DNA/Polymer Nanoparticles for Tumor-Targeted Delivery – Hai-Quan Mao, Honggang Cui, and Martin G. Pomper
  • Regulation of the Invasive Transition by Nanoscale Adhesive Features in the Tumor Microenvironment – Jennifer Elisseeff and Andrew Ewald
  •  A Targeted Theranostic Nanoprobe for Real-time Imaging of HSV1-tk in Brain Tumors – Assaf A. Gilad, Arvind P. Pathak, Yoshinori Kato

Funded Pilot Projects 2011

  • Thermo-chemoembolization for treatment of liver cancer. PI: Eleni Liapi, MD; Interventional Radiology, School of Medicine. Co-Inv: Robert Ivkov, PhD; Radiation Oncology, School of Medicine
  • Biodegradable, Shape Shifting Nanoparticles as Artificial Antigen Presenting Cells. PI: Jonathan Schneck, MD, PhD; Pathology and Oncology; School of Medicine. Co-Inv: Jordan Green, PhD; Biomedical Engineering; School of Medicine
  • A model system to determine the influence of active and passive systemic tumor targeting. PI: Shawn Lupold, PhD; Urology and Oncology, School of Medicine. Co-Inv: Martin Pomper, MD, PhD; Radiology, School of Medicine