The objective of the Center of Cancer Nanotechnology Excellence is to integrate nanotechnology-based diagnostic and therapeutic tools for comprehensive cancer care. We envision a set of integrated nanotechnology-based solutions for diagnosis, therapy, and post-therapy monitoring. Combining novel in vitro assays with targeted chemotherapy and immunotherapy we can establish a new paradigm in cancer nanomedicine. Our overall objective is to demonstrate that nanotechnology-based tools can be integrated for comprehensive cancer care.