Prizes offered for top poster presenters

We need your posters! INBT’s annual symposium theme relates to neuroscience, but posters on any multidisciplinary topic are encouraged. Submission deadline for posters is April 27. Posters will be judged and prizes will be awarded to top presenters!

Erlenmeyer_Flasks.-awardJohns Hopkins Institute for NanoBioTechnology hosts its annual symposium May 1 in the Owens Auditorium (between CRB I and CRB II) at the medical campus. Faculty expert speakers present in the morning on our theme, Neuro X, where x can be medicine, engineering, science, etc. The poster session begins in the afternoon. Posters on ANY MULTIDISCIPLINARY TOPIC are encouraged, and we welcome submissions from any department or division. Prizes will be awarded to top presenters. Submission guidelines, the full speaker agenda and additional information can be found online. Submit your poster now at http://inbt.jhu.edu/news/symposium/

Poster presenters sought for Neuro X symposium

Johns Hopkins Institute for NanoBioTechnology (INBT) hosts its ninth annual symposium on May 1, 2015 in the Owens Auditorium on the Johns Hopkins medical campus. The theme for the speakers this year is Neuro X, where X stands for medicine, nanotechnology, engineering, science and more! Posters on any multidisciplinary theme are now being accepted. You do not have to be a member of an INBT affiliated laboratory to participate. Undergraduates, graduate students and postdoctoral fellows welcome. The event is free for Johns Hopkins associated persons. There is a fee for those outside of JHU/JHMI/JHH and is listed on the registration form.

Full details on poster guidelines and current information on the symposium can be found on the Neuro X website. To submit a poster or to simply register to attend the symposium, click here.

neuro-x-ad-flatThe symposium will begin at 8 a.m. with continental breakfast. Talks will begin at 9 a.m. and continue through 12:15 p.m. Speakers include: Alfredo Quiñones-Hinojosa, MD, FAANS, Professor of Neurological Surgery and Oncology Neuroscience and Cellular and Molecular Medicine; Jordan J. Green, PhD, Associate Professor of Biomedical Engineering, Ophthalmology, Neurosurgery, and Materials Science & Engineering; Ahmet Hoke MD, PhD, FRCPC, Professor, Neurology and Neuroscience; Patricia H. Janak, Professor, Department of Psychological and Brain Sciences/Department of Neuroscience in the Krieger School of Arts and Sciences; Piotr Walczak, MD, PhD, Associate Professor, Department of Radiology and Radiological Science; and Martin G. Pomper, MD, PhD, the William R. Brody Professor of Radiology and Radiological Science. This year’s symposium chairs are INBT director Peter Searson, Reynolds Professor, Materials Science and Engineering, and Dwight Bergles, Professor, the Solomon H. Snyder Department of Neuroscience, Department of Otolaryngology, Head & Neck Surgery.

The poster session will begin at 1:15 p.m. and conclude at 3:30 p.m. with poster prize presentations. Speaker talk titles, poster prizes and other details will be announced in the next few weeks. Don’t miss your chance to participate in one of Johns Hopkins largest, most popular and most well attended symposiums. Plan now to attend and present.

For all press inquiries regarding INBT, its faculty and programs, contact INBT’s science writer Mary Spiro, mspiro@jhu.edu or 410-516-4802.

 

 

 

Hanes discusses nanoparticle-based drug delivery

Justin Hanes was among the invited speakers at the 2012 NanoBio Symposium.

“Would you poison the entire garden to kill one weed?” asked Justin Hanes at the opening of his talk at the 2012 Johns Hopkins annual NanoBio Symposium. “Unfortunately, that is how most chemotherapy works today.” Hanes is a professor of ophthalmology at Johns Hopkins School of Medicine and an affiliated faculty member of the Institute for NanoBioTechnology.

On average, less than one percent of any chemotherapy cancer treatment will go to a patient’s tumor. The remaining 99 percent circulates through the rest of the patient’s body, kills healthy cells unnecessarily, and causes often unbearable side effects. This alarming statistic has led Hanes and his team to focus on targeted, chemotherapeutic drug delivery using nanoparticles.

Hanes explained that nanoparticles are ideal in cancer treatment because tumors form new blood vessels within themselves to be able to receive nutrients, and these tumor-associated blood vessels are leaky. Thin, leaky blood vessel walls are ideal for drug-loaded nanoparticles, which are on the order of 1-100 nanometers in diameter, to break through to reach tumor cells. The ultimate goal of nanoparticle drug delivery for cancer is to synthesize bio-targeted particles that provide localized delivery straight to the tumor alone, improving drug effectiveness and reducing undesirable side effects.

Many members of the Hanes lab focus on drug delivery in mucus, which exists in the lining of the lungs, vaginal tract, intestines, and many other organs. Although mucus is essential to prevent viruses and bacteria from entering tissues, its sticky consistency also acts as a barrier to drug-loaded nanoparticles. Hanes’s students are synthesizing nanoparticles that can pass through mucosal barriers.

Scientists previously believed that pores within mucus were around 25 nm in size and that nanoparticles would not be able to pass through. However, the Hanes lab’s work shows that these pores may be closer to 400 nm and that particles with a diameter of 500 nm coated with a simple, biodegradable polymer called PEG can pass through. The PEG gives the particles a neutral charge and makes them hydrophilic, or attracted to water, so that they can pass easily through the mucosal meshwork without getting trapped.

The group is now able to encapsulate chemotherapeutic drugs in mucus-penetrating nanoparticles for a variety of different applications, including lung cancer and ovarian cancer. Additionally, Laura Ensign, an INBT-sponsored graduate student in the Hanes lab, showed in a recently-published journal article that her mucus-penetrating particles effectively delivered drugs in the mouse vaginal tract for longer times than previously reported (>24 h). This work could be applied to cervical cancer, where drug-loaded nanoparticles could be administered to travel through the mucosal lining of the reproductive tract for successful treatment.

Overall, the Hanes lab anticipates that their research will contribute to the effectiveness of many types of cancer treatments. Read more about Ensign’s recently published work here.

Story by Allison Chambliss, a Ph.D. student in the Department of Chemical and Biomolecular Engineering with interests in cellular biophysics and epigenetics.

 

Four students honored at INBT research symposium

Spyros Stamatelos with INBT director Peter Searson. Photo by Mary Spiro

Four students were honored for their research efforts at Johns Hopkins Institute for NanoBioTechnology’s sixth annual symposium. A poster session with more than 75 research posters from every division of the university was held in the afternoon and four posters were selected for top honors.

A poster by Yu-Ja Huang, Justin Samorajski, Rachel Kreimer, Denis Wirtz and Peter Searson won first prize, and first author Huang was awarded the $200 gift card from Best Buy. Their poster was entitleThe Influence of Electric Field and Confinement on U-87 Glioblastoma Cells.

Taking second place was Anirudha Sing, Jianan Zhan and Jennifer Elisseeff with the poster Directed Stem Cell Differentiation Using PEG-alpha CD-derived biomaterials. First author Singh claimed the $100 Best Buy card.

A $50 Best Buy card was presented to Spyros Stamatelos who was first author with Eugene Kim, Arvind Pathak and Aleksander Popel on the poster Characterization of the Heterogeneity of Tumor Vasculature using Hemodynamic Modeling and High Resolution Imaging Implications for Drug Delivery.

Honorable mention was given to Jack Andraka, a high school research intern in the lab of Anirban Maitra who worked with Venugopal Chenna. Andraka’s poster, A Novel Paper Sensor for the Detection of Pancreatic Cancer, helped him win a free book from Springer.

Jack Andraka describing his research at the INBT poster session. Photo by Mary Spiro

The event was held  at the Johns Hopkins medical campus in the Owens Auditorium on May 4 with six faculty expert speakers and approximately 400 people in attendance.

 

Nano-Bio magazine published for 2012 symposium

The third edition of  Nano-Bio Magazine has been published in conjunction the sixth annual symposium of Johns Hopkins Institute for NanoBioTechnology. The symposium will be held May 4, 2012 at the Owens Auditorium in the Koch Cancer Research Building on the medical campus of the Johns Hopkins University. Talks begin at 9 a.m. A poster session begins at 1:30 p.m. More information on the symposium can be found here.

This year’s magazine features an interview with symposium keynote speaker Ralph Hruban about the state-of-the-art in early diagnosis of pancreatic cancer. Hruban directs the Sol Goldman Pancreatic Cancer Research Center at Johns Hopkins.

In addition, there are comprehensive features on INBT’s international research experience program as well as the institute’s support of undergraduate research. The magazine also includes a profile of one of INBT”s corporate partners, BD, an essay on the use of videos to explain science, and many other stories about INBT.

We hope you enjoy this year’s copy of Nano-Bio Magazine. It serves as a program for the symposium as well as an outlet to feature many of INBT’s programs and achievements.

You can read Nano-Bio Magazine online or download a pdf at this link.

Students talk cancer nanotech at Homewood March 21

Students affiliated with the Center of Cancer Nanotechnology Excellence (CCNE) and the Physical Sciences-Oncology Center (PS-OC) at Johns Hopkins University have organized a spring mini-symposium for March 21, 10 a.m. in the Hackerman Hall Auditorium at the Johns Hopkins University Homewood campus.

The student-run mini-symposiums aim to bring together researchers from across the campus affiliated with the PS-OC and CCNE. Graduate students training in these centers, both administered by Johns Hopkins Institute for NanoBioTechnology, work in various disciplines from physics to engineering to the basic biological sciences but with an emphasis on understanding cancer metastasis and developing methods for cancer diagnosis or therapy.

The invited speaker for the symposium is postdoctoral researcher Megan Ho of Duke University. Ho earned her PhD in mechanical engineering in the Wang lab in 2008. She is currently focused on developing microfluidic devices to investigate and control the fundamental reactions that form nanocomplexes for gene delivery. (10 a.m.)

Student apeakers, who will talk for 15 minutes, include:

  • Jane Chisholm (Justin Hanes lab/Ophthalmology): Cisplatin nanocomplexes for the local treatment of small cell lung cancer (10:20 a.m.)
  • Yunke Song (Jeff Wang Lab/Mechanical Engineering): Single Quantum Dot-Based Multiplexed Point Mutation Detection by Gap Ligase Chain Reaction (10:35 a.m.)
  • Andrew Wong (Peter Searson Lab/Materials Science and Engineering): Intravisation into an artificial blood vessel (10:50 a.m.)
  • Brian Keeley: (Jeff Wang Lab/Mechanical Engineering): Overcoming detection limitations of DNA methylation in plasma and serum of cancer patients through utilization of nanotechnology. (11:05 a.m.)
  • Sebastian Barretto (Sharon Gerecht Lab/Chemical and Biomolecular Engineering): Development of Hydrogel Microfibers to Study Angiogenesis (11:20 a.m.)

View the symposium flyer here. The mini-symposium is free and open to the entire Johns Hopkins University community. No RSVP is required, although seating is limited.

Johns Hopkins Physical Sciences-Oncology Center

Center of Cancer Nanotechnology Excellence

Hopkins to host colloid, surface science symposium

The Johns Hopkins University is hosting the 86th American Chemical Society’s Colloid and Surface Science Symposium in Baltimore, MD on June 10-13, 2012. The meeting includes 13 parallel sessions, a poster session, 28 invited speakers, and 28 session organizers. A new addition to this meeting is the Langmuir Student Awards presentation session with application details given on the conference website.

Abstract submission is now open and the deadline is February 7, 2012. Up-to-date information on the meeting can be found at the website: www.colloids2012.org.

For further details about this meeting please contact the symposium co-organizers Mike Bevan (mabevan@jhu.edu) and Joelle Frechette (jfrechette@jhu.edu). Bevan and Frechette are affiliated faculty members of Johns Hopkins Institute for NanoBioTechnology and members of the Department of Chemical and Biomolecular Engineering.

Download the symposium flyer here.

 

Agenda set for Oct. 10 mini-symposium on cancer, nanotech

From the spring mini-symposium.

Johns Hopkins Physical Sciences-Oncology Center and Center of Cancer Nanotechnology Excellence will host a mini-symposium on Monday Oct., 10 in the Hackerman Hall Auditorium. Talks on topics related to cancer and nanotechnology begin at 9 a.m.

Speakers include:

  • 9:15 a.m.: The pulsating motion of breast cancer cell is regulated by surrounding epithelial cells. Speaker: Meng Horng Lee
  • 9:40 a.m.: Breast tumor extracellular matrix promotes vasculogenesis. Speaker: Abigail Hielscher
  • 10:00 a.m.: Attachment to growth substrate regulates expression of GDF15, an important molecule in metastatic cancer. Speaker: Koh Meng Aw Yong
  • 10:20 a.m.: Mucin 16 is a functional selectin ligand on pancreatic cancer cells. Speaker: Jack Chen
  • 10:40 a.m.: Particle tracking in vivo. Speaker: Pei-Hsun Wu

These talks are open to the entire Hopkins community. No RSVP is required. Refreshments will be served.

 

 

Breast cancer highlighted at Homewood mini-symposium

A tumor cell breaking free and entering the blood stream. (From animation by Ella McCrea, Nathan Weiss and Martin Rietveld)

Breast cancer will be topic of at least two of the talks planned for a mini-symposium October 10 on the Homewood campus.

UPDATED: Click here for updated list of talk titles.

Students from Johns Hopkins Physical Sciences-Oncology Center (PSOC) and Center of Cancer Nanotechnology Excellence (CCNE) will hold their second mini-symposium of the year on October 10 at 9 a.m. in Hackerman Hall Auditorium. The symposia, scheduled each spring and fall on the Homewood campus, encourage an exchange of ideas between PhD students and postdoctoral fellows associated with these centers. The entire Hopkins community is invited to attend, and no RSVP is required.

Some of the talk titles include, from the department of Chemical and Biomolecular Engineering, “The Pulsing Motion of Breast Cancer Cell is Regulated by Surrounding Epithelial Cells” presented by Meng Horng Lee, a PSOC postdoctoral fellow in the Denis Wirtz lab; “Breast Tumor Extracellular Matrix Promotes Vasculogenesis” presented by Abigail Hielscher, a postdoctoral fellow in the Sharon Gerecht lab; and “Mucin 16 is a Functional Selectin Ligand on Pancreatic Cancer Cells” given by Jack Chen, a pre-doctoral fellow in the lab of Konstantinos Konstantopoulos. Additional speakers include postdoctoral fellow Pei-Hsun Wu, PhD, a from the Wirtz Lab and Koh Meng Aw Yong, a pre-doctoral student affiliated with Princeton University’s Physical Sciences-Oncology Center.

The purpose of these twice a year, student run mini-symposia is to facilitate communication among researchers working in laboratories studying the mechanistic aspects of cancer spread (i.e., those affiliated with the PSOC) and those working on novel means of using nanotechnology for cancer diagnosis or treatment (i.e., those associated with the CCNE). Anjil Giri coordinated the fall mini-symposium, a PSOC pre-doctoral fellow in the Wirtz lab , with Erbil Abaci, a PSOC pre-doctoral fellow with in the Gerecht lab. Visit the INBT website (inbt.jhu.edu) for further details, as additional speakers and talk titles will be announced.

Hopkins Imaging Initiative to host first annual conference

The Johns Hopkins University Imaging Initiative will host the first annual Imaging Conference, October 6, 2011 at the Turner Auditorium on the medical campus. The conference features afternoon lectures from various Hopkins faculty followed by a research poster session and happy hour. Anyone interested in imaging is welcome to attend.

Speakers include Elliot McVeigh, director of the Department of Biomedical Engineering; Elliot Fishman, MD, director of diagnostic imaging at body CT at Johns Hopkins Hospital; Jerry Prince, the William B. Kouwenhoven Professor of Electrical and Computer Engineering at the Whiting School of Engineering; Xingde Li, associate professor of biomedical engineering and head of the Laboratory of Biophotonics Imaging and Therapy at the Whiting School; Peter van Zijl, professor of radiology at the school of medicine and director of the F.M. Kirby Research Center for Functional Brain Imaging; and several others to be announced.

Abstracts will be accepted until Sept 6 and conference registration will be accepted until October 1. For complete information about this event and to register, go to http://imaging.jhu.edu/conferences/imaging-conference-2011